This strain was a conditional mouse model expressing the human LPA gene, where the loxP-Stop-loxP-hLPA sequence was inserted into the intron 1 of the ROSA26 safe harbor locus. When this model is bred with mice expressing Cre recombinase, sequence recombination occurs in the Cre-positive cells and tissues of the offspring mice. After the Cre-recombinase-mediated deletion of the stop element (LSL), specific expression of the human LPA gene can be achieved. The B6-hLPA (CKI) mice can be used for research related to atherosclerosis, and thrombotic cardiovascular diseases, as well as the development, screening, and preclinical evaluation of human LPA gene-targeted drugs.