B6-hCALCA
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Strain Description
This strain is a humanized mouse model of the Calca gene. Using gene editing technology, the base sequence of the mouse Calca gene from the start codon to the 3’UTR region was replaced by the corresponding sequence in the human CALCA gene, while the 5’UTR region of the mouse Calca gene was retained. Homozygous B6-hCALCA mice are viable and fertile and can be used to study the mechanisms of various physiological and pathological processes such as blood pressure regulation, cell proliferation, cell apoptosis, vascular biology, physiological bone marrow production, inflammation, tumor growth, and research on CALCA-targeted migraine drugs and therapies.
Application Area
Discovery and screening of migraine drugs and therapies
Evaluation of the efficacy and safety of migraine drugs and therapies
Research on vascular biology and blood pressure regulation
Research on cell proliferation and apoptosis
Research on tumor growth inhibition and inflammation
Research on the generation and differentiation of hematopoietic stem/progenitor cells
Detailed Information