B6-hIgA1
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hIgA1
Product ID
C001565
Gene Name
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Background
C57BL/6NCya
Gene Alias
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Classification
Immune Target Humanized Models,Full-Gene Humanized Models
NCBI ID
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Phenotype
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Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hIgA1 mice (Catalog C001565) were purchased from Cyagen.”
Strain Description
The B6-hIgA1 mouse is a humanized model constructed by inserting the human IGHA1 gene sequence into the region between the mouse IgM enhancer (Eμ) and IgM constant region (Cμ), replacing the mouse IgM switch region (Sμ). B6-hIgA1 mice successfully express the human IGHA1 gene, and high levels of human IgA1 protein can be detected in their serum. Therefore, B6-hIgA1 mice can be used to study B cell development, immunoglobulin formation, and autoimmune mechanisms. They can also be crossed with CD89 humanized mouse models (catalog number: C001563) to create IgA nephropathy (IgAN) mouse model that better reflect human genetic mechanisms and pathological phenotypes [4], facilitating the development of IgA1-targeted drugs.
Application Area
Research on B cell development, immunoglobulin formation, and autoimmune mechanisms
Construction and efficacy evaluation of IgA nephropathy (IgAN) models
Preclinical evaluation of IgA1-targeted therapies
Validation Data