DBA/1-hTNF
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
DBA/1-hTNF
Product ID
C001587
Gene Name
Background
DBA/1
Gene Alias
DIF; TNFA; IMD127; TNFSF2; TNLG1F; TNF-alpha
Classification
Cytokine Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
6
Document
Note: When using this mouse strain in a publication, please cite “DBA/1-hTNF mice (Catalog C001587) were purchased from Cyagen.”
Strain Description
The DBA/1-hTNF mice is a mouse Tnf gene humanized model. The mouse Tnf gene in the DBA/1 strain is replaced with the human TNF gene, including the 5’UTR and 3’UTR. This model is useful for diseases researches such as rheumatoid arthritis (RA). Since immunization of DBA/1 mice with type II collagen leads to severe polyarthritis mediated by the autoimmune response, DBA/1 mice are widely used for RA model construction. Therefore, DBA/1-hTNF mice constructed on a DBA/1 strain background can be used to research immune-related diseases such as RA.
Application Area
Research on Rheumatoid Arthritis (RA)
Research on TNF-α signaling pathway
Research on the pathogenesis and treatment of other TNF-α related diseases
Validation Data