B6-hMASP2
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hMASP2
Product ID
C001592
Gene Name
Background
C57BL/6NCya
Gene Alias
sMAP; MAP-2; MAP19; MASP-2; MASP1P1
Classification
Immune Target Humanized Models,Metabolic Target Humanized Models,Cytokine Humanized Models,Metabolic Disease Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “B6-hMASP2 mice (Catalog C001592) were purchased from Cyagen.”
Strain Description
The B6-hMASP2 mouse model, generated through precise gene editing technology, features the in situ replacement of part of the endogenous mouse Masp2 gene with the coding sequence (CDS) of human MASP2. Homozygous B6-hMASP2 mice are viable and fertile, providing a robust platform for studying the pathophysiology of autoimmune and infectious diseases. This model also serves as a valuable tool for the development and preclinical evaluation of MASP-2-targeted therapeutics, offering insights into both mechanistic and translational aspects of complement-mediated diseases.
Application Area
MASP2-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of autoimmune and infectious diseases
Validation Data