B6-h4-1BB (TNFRSF9)
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Strain Description
The B6-h4-1BB (TNFRSF9) mouse is a humanized model. The sequence encoding the endogenous extracellular domain of the mouse Tnfrsf9 is replaced in situ with the sequence encoding the human TNFRSF9 extracellular domain. This model can be used for studies on cancer immunology and autoimmune diseases, as well as for the development, screening, and evaluation of 4-1BB agonists in preclinical research.
Application Area
Research on cancer immunotherapy and autoimmune diseases
Preclinical studies on the development, screening, and evaluation of 4-1BB agonists
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