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B6-hANG2 (ANGPT2)
Product ID:
C001615
Background:
C57BL/6JCya
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Strain Description
B6-hANG2 (ANGPT2) mouse model was generated using gene editing technology to replace the entire sequence of the mouse Angpt2 gene with the human ANGPT2 gene sequence, achieving stable expression of human ANGPT2 protein. This model is suitable for studying tumorigenesis, vascular hyperproliferative diseases (e.g., diabetic retinopathy, age-related macular degeneration), autoimmune disorders, and preclinical evaluation of human ANGPT2-targeted therapeutics.
Application Area
Area
Mechanistic studies of tumorigenesis and cancer progression
Area
Pathogenesis of vascular diseases and autoimmune disorders
Area
Development, screening, and preclinical pharmacodynamic evaluation of human ANGPT2-targeted therapeutics
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