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B6-hHER2 (hERBB2)
Product ID:
C001627
Background:
C57BL/6NCya
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Strain Description
The B6-hHER2(ERBB2) mouse is a humanized model constructed using gene editing technology, where the mouse HER2 extracellular domain (aa.25~653) was replaced with the human HER2 extracellular domain (aa.25~652). Homozygous B6-hHER2(ERBB2) mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of relative cancers, and for the development of HER2-targeted drugs.
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HER2-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of HER2-positive cancers
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