B6-hHER2 (hERBB2)
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Genotype
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Basic Information
Model Name
B6-hHER2 (hERBB2)
Product ID
C001627
Gene Name
Background
C57BL/6NCya
Gene Alias
NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2)
Classification
Tumor Target Humanized Models
NCBI ID
Phenotype
Chromosome
17
Document
Note: When using this mouse strain in a publication, please cite “B6-hHER2 (hERBB2) mice (Catalog C001627) were purchased from Cyagen.”
Strain Description
The B6-hHER2(ERBB2) mouse is a humanized model constructed using gene editing technology, where the mouse HER2 extracellular domain (aa.25~653) was replaced with the human HER2 extracellular domain (aa.25~652). Homozygous B6-hHER2(ERBB2) mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of relative cancers, and for the development of HER2-targeted drugs.
Application Area
HER2-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of HER2-positive cancers
Validation Data