B6-hIL1RL1 (hIL33R)
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hIL1RL1 (hIL33R)
Product ID
C001632
Gene Name
Background
C57BL/6NCya
Gene Alias
T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
--
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hIL1RL1 (hIL33R) mice (Catalog C001632) were purchased from Cyagen.”
Strain Description
The B6-hIL1RL1 mouse is a humanized model constructed using gene editing technology, where the mouse IL1RL1 signal peptide and endogenous extracellular domain (aa.1~332) were replaced with the human IL1RL1 signal peptide and extracellular domain (aa.1~328). The murine IL1RL1 transmembrane and cytoplasmic region (aa.333~567) were preserved. Homozygous B6-hIL1RL1 mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of cancer, inflammatory, and immune-related diseases, and for the development of IL1RL1-targeted drugs.
Application Area
IL1RL1-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of cancer, inflammatory, and immune-related diseases
Validation Data