B6-hIL7R
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hIL7R
Product ID
C001633
Gene Name
Background
C57BL/6NCya
Gene Alias
ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Cytokine Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
5
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Note: When using this mouse strain in a publication, please cite “B6-hIL7R mice (Catalog C001633) were purchased from Cyagen.”
Strain Description
The B6-hIL7R mouse is a humanized model constructed using gene editing technology, where the mouse IL7R endogenous extracellular domain (aa.21~239) was replaced with the human IL7R extracellular domain (aa.21~239). The murine IL7R signal peptide and cytoplasmic region (aa.1~20, aa.240~459) was preserved. Homozygous B6-hIL7R mice are viable and fertile. This model can be used for studying the pathological mechanisms and therapeutic approaches of autoimmune diseases, immunodeficiency, and cancer, and for the development of IL7R-targeted drugs.
Application Area
IL7R-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases, immunodeficiency, and cancer
Validation Data