B6-hITGB7
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hITGB7
Product ID
C001637
Gene Name
Background
C57BL/6NCya
Gene Alias
--
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
12
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Note: When using this mouse strain in a publication, please cite “B6-hITGB7 mice (Catalog C001637) were purchased from Cyagen.”
Strain Description
The B6-hITGB7 mouse is a humanized model constructed using gene editing technology, where the mouse Itgb7 endogenous extracellular domain (aa.20~724) was replaced with the human ITGB7 extracellular domain (aa.20~723). The murine signal peptide (aa.1~19) was preserved. This model can be used for studying the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases, and for the development of ITGB7-targeted drugs.
Application Area
ITGB7-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases
Validation Data