B6-Pnpla3*I148M
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-Pnpla3*I148M
Product ID
C001692
Gene Name
Background
C57BL/6JCya
Gene Alias
Adpn
Classification
Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
15
Document
Note: When using this mouse strain in a publication, please cite “B6-Pnpla3*I148M mice (Catalog C001692) were purchased from Cyagen.”
Strain Description
B6-Pnpla3*I148M mice are obtained by introducing the I148M mutation into the mouse Pnpla3 gene using gene editing technology. Homozygous B6-Pnpla3*I148M mice are viable and fertile. This model can be used for research on the disease mechanisms and treatment methods of metabolism-associated fatty liver disease (MASLD), alcoholic liver disease, and liver fibrosis.
Application Area
Research on the disease mechanisms and treatment methods of metabolism-associated fatty liver disease (MASLD), alcoholic liver disease, liver fibrosis, etc.
Research on PNPLA3 I148M inhibitors
Validation Data