B6-H11-hBDCA2 (hCLEC4C)
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Strain Description
B6-H11-hCLEC4C mice are humanized models generated by gene editing technology, in which the human CLEC4C genomic DNA was inserted at the H11 safe harbor. This modification does not affect the expression of the mouse homologous gene Clec4b1. This model can be used to study the pathological mechanisms and therapeutic methods of autoimmune disorders and hematological malignancies, as well as the screening and development of CLEC4C-targeted drugs, and preclinical efficacy and safety evaluations.
Application Area
Screening, development, and preclinical efficacy evaluation of CLEC4C-targeted drugs
Study of pathological mechanisms and therapeutic methods for autoimmune disorders
Study of pathological mechanisms and therapeutic methods for hematological malignancies
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