B6-hC5AR1
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hC5AR1
Product ID
C001714
Gene Name
Background
C57BL/6NCya
Gene Alias
C5A; C5AR; C5R1; CD88
Classification
Tumor Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
19
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Note: When using this mouse strain in a publication, please cite “B6-hC5AR1 mice (Catalog C001714) were purchased from Cyagen.”
Strain Description
The B6-hC5AR1 mouse is a humanized model constructed by replacing the partial intron 1 (~2 kb) to TAG stop codon of the mouse C5ar1 gene in situ with the corresponding sequence from the human C5AR1 gene. B6-hC5AR1 mice can be used for the research on the pathogenesis of various inflammatory diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease, neuroinflammation related to Alzheimer's disease, and some tumors, as well as for C5AR1-targeted drug development.
Application Area
C5AR1-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of various inflammatory diseases and autoimmune diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease
Research on the neuroinflammation related to Alzheimer's disease and some tumors
Validation Data