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B6-hC5AR1
Product ID:
C001714
Background:
C57BL/6NCya
Documents:
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Strain Description
The B6-hC5AR1 mouse is a humanized model constructed by replacing the partial intron 1 (~2 kb) to TAG stop codon of the mouse C5ar1 gene in situ with the corresponding sequence from the human C5AR1 gene. B6-hC5AR1 mice can be used for the research on the pathogenesis of various inflammatory diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease, neuroinflammation related to Alzheimer's disease, and some tumors, as well as for C5AR1-targeted drug development.
Application Area
Area
C5AR1-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of various inflammatory diseases and autoimmune diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease
Area
Research on the neuroinflammation related to Alzheimer's disease and some tumors
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