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B6-hIL1A
Product ID:
C001717
Background:
C57BL/6NCya
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Strain Description
The B6-hIL1A mice are a humanized model constructed by replacing the mouse Il1a gene sequence and the 3' UTR region in situ with the corresponding sequence of the human IL1A gene. The B6-hIL1A mice can be used for the research of diseases such as rheumatoid arthritis, ankylosing spondylitis, chronic periodontitis, Alzheimer's disease (AD) and related vascular dementia, diabetes mellitus, systemic sclerosis, autoimmune encephalomyelitis, and cerebral infarction, and for IL1A-targeted drugs development.
Application Area
Area
IL1A-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of diseases such as rheumatoid arthritis, ankylosing spondylitis, chronic periodontitis, Alzheimer's disease and related vascular dementia, diabetes mellitus, systemic sclerosis, autoimmune encephalomyelitis, and cerebral infarction
Area
Research on other chronic inflammatory diseases, autoimmune diseases, and certain cancers
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