B6-hIL1A Mouse
Product Name
B6-hIL1A Mouse
Product ID
C001717
Strain Name
C57BL/6NCya-Il1atm1(hIL1A)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “B6-hIL1A Mouse (Catalog C001717) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
IL1A
Gene Alias
IL1, IL-1A, IL1F1, IL1-ALPHA, IL-1 alpha
NCBI ID
Chromosome
Chr 2 (Human)
MGI ID
Datasheet
Strain Description
Interleukin-1 alpha (IL-1α), encoded by the IL1A gene, is a critical pleiotropic cytokine that plays a central role in the initiation and propagation of inflammatory responses and the regulation of innate immunity [1]. Primarily expressed by monocytes, macrophages, dendritic cells, and epithelial cells in response to cellular stress, damage, or pathogen recognition, IL-1α can exert its effects both as a precursor within the cell or upon release through non-classical secretory pathways. This cytokine triggers a cascade of downstream signaling events, influencing diverse biological processes including fever induction, acute-phase protein synthesis, and the activation and recruitment of immune cells to sites of inflammation [2]. While essential for host defense and tissue repair, dysregulation of IL1A expression and signaling is implicated in the pathogenesis of various diseases, including rheumatoid arthritis, ankylosing spondylitis, chronic periodontitis, and potentially osteoarthritis and certain cancers, highlighting its significance as a potential therapeutic target [3].
The B6-hIL1A mice are a humanized model constructed by replacing the mouse Il1a gene sequence and the 3' UTR region in situ with the corresponding sequence of the human IL1A gene. The B6-hIL1A mice can be used for the research of diseases such as rheumatoid arthritis, ankylosing spondylitis, chronic periodontitis, Alzheimer's disease (AD) and related vascular dementia, diabetes mellitus, systemic sclerosis, autoimmune encephalomyelitis, and cerebral infarction, and for IL1A-targeted drugs development.
Reference
Galozzi P, Bindoli S, Doria A, Sfriso P. The revisited role of interleukin-1 alpha and beta in autoimmune and inflammatory disorders and in comorbidities. Autoimmun Rev. 2021 Apr;20(4):102785.
Dinarello CA. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 2018 Jan;281(1):8-27.
Calabrese L, Fiocco Z, Satoh TK, Peris K, French LE. Therapeutic potential of targeting interleukin-1 family cytokines in chronic inflammatory skin diseases. Br J Dermatol. 2022 Jun;186(6):925-941.
Strain Strategy
Figure 1. Gene editing strategy of B6-hIL1A Mice. The sequences from ATG start codon to 3’UTR of the endogenous mouse Il1a gene were replaced with the sequences from ATG start codon to 3’UTR of the human IL1A gene.
Application Area
IL1A-targeted drug screening, development, and evaluation;
Research on the pathological mechanisms and therapeutic approaches of diseases such as rheumatoid arthritis, ankylosing spondylitis, chronic periodontitis, Alzheimer's disease and related vascular dementia, diabetes mellitus, systemic sclerosis, autoimmune encephalomyelitis, and cerebral infarction;
Research on other chronic inflammatory diseases, autoimmune diseases, and certain cancers.
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