B6-hIL1A
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hIL1A
Product ID
C001717
Gene Name
Background
C57BL/6NCya
Gene Alias
IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Neurological Disease Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hIL1A mice (Catalog C001717) were purchased from Cyagen.”
Strain Description
The B6-hIL1A mice are a humanized model constructed by replacing the mouse Il1a gene sequence and the 3' UTR region in situ with the corresponding sequence of the human IL1A gene. The B6-hIL1A mice can be used for the research of diseases such as rheumatoid arthritis, ankylosing spondylitis, chronic periodontitis, Alzheimer's disease (AD) and related vascular dementia, diabetes mellitus, systemic sclerosis, autoimmune encephalomyelitis, and cerebral infarction, and for IL1A-targeted drugs development.
Application Area
IL1A-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of diseases such as rheumatoid arthritis, ankylosing spondylitis, chronic periodontitis, Alzheimer's disease and related vascular dementia, diabetes mellitus, systemic sclerosis, autoimmune encephalomyelitis, and cerebral infarction
Research on other chronic inflammatory diseases, autoimmune diseases, and certain cancers
Validation Data