B6-hTROP2 (hTACSTD2)
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Basic Information
Model Name
B6-hTROP2 (hTACSTD2)
Product ID
C001718
Gene Name
Background
C57BL/6NCya
Gene Alias
EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
Classification
Tumor Target Humanized Models
NCBI ID
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “B6-hTROP2 (hTACSTD2) mice (Catalog C001718) were purchased from Cyagen.”
Strain Description
The B6-hTROP2 (hTACSTD2) mouse is a humanized model constructed by replacing the signal peptide and extracellular domain (aa.1~270) of the mouse Tacstd2 with the corresponding signal peptide and extracellular domain (aa.1~274) from the human TACSTD2 gene. The B6-hTROP2 (hTACSTD2) mice can be used for studies on pathogenesis of various cancers, as well as for TACSTD2-targeted drug development.
Application Area
TACSTD2-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of various cancers
Research on the pathological mechanisms and therapeutic approaches of gelatinous drop-like corneal dystrophy
Validation Data