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B6-hCD40
Product ID:
C001721
Background:
C57BL/6NCya
Documents:
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Strain Description
The B6-hCD40 mouse is a humanized model constructed by replacing the endogenous extracellular domain (aa.20~193) of the mouse Cd40 with the corresponding extracellular domain (aa.21~193) from the human CD40 gene. The murine signal peptide (aa.1~19) and transmembrane-cytoplasmic region (aa.194~289) were preserved. The B6-hCD40 mice can be used for studies on pathogenesis of cancer and autoimmune diseases, as well as for CD40-targeted drug development.
Application Area
Area
CD40-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of various cancers
Area
Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases
Area
Research on the pathological mechanisms and therapeutic approaches of cardiovascular diseases and neurological disorders
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