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B6-hCLEC4C
Product ID:
C001726
Background:
C57BL/6NCya
Documents:
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Basic Information
Model Name
B6-hCLEC4C
Product ID
C001726
Gene Name
CLEC4C
Background
C57BL/6NCya
Gene Alias
DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150
Classification
Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
170482
Phenotype
MGI:1917060
Chromosome
12
More
Rare Disease Data Center >>
Document
Click here to download >>
Note
Note: When using this mouse strain in a publication, please cite “B6-hCLEC4C mice (Catalog C001726) were purchased from Cyagen.”
Strain Description
The B6-hCLEC4C mouse is a humanized model constructed by replacing the mouse Clec4b1 endogenous extracellular domain (aa.42~209) with the human CLEC4C extracellular domain (aa.45~213). This model can be used to study the pathological mechanisms and therapeutic methods of autoimmune disorders and hematological malignancies, as well as the screening and development of CLEC4C-targeted drugs, and preclinical efficacy and safety evaluations.
Application Area
Area
Screening, development, and preclinical efficacy evaluation of CLEC4C-targeted drugs
Area
Study of pathological mechanisms and therapeutic methods for autoimmune disorders
Area
Study of pathological mechanisms and therapeutic methods for hematological malignancies
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