Cfh KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Cfh KO
Product ID
C001776
Gene Name
Background
C57BL/6JCya
Gene Alias
NOM; Sas1; Mud-1; Sas-1
Classification
Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “Cfh KO mice (Catalog C001776) were purchased from Cyagen.”
Strain Description
The Cfh KO mouse is a gene knockout model created using gene-editing techniques to knock out the Exon 2~3 of the Cfh gene (the homolog of the human CFH gene) in mice. This model can be used for research into the pathogenic mechanisms of diseases such as age-related macular degeneration, atypical hemolytic uremic syndrome, C3 glomerulopathy, and Type II membranoproliferative glomerulonephritis, as well as for the development of related treatment methods.
Application Area
Research on the regulatory mechanisms of the complement system
Atypical hemolytic uremic syndrome (aHUS) pathogenesis research and treatment drug assessment
Age-related macular degeneration (AMD) pathological model construction and intervention strategy development
Mechanistic exploration of complement overactivation in autoimmune diseases
Pathological research of kidney diseases associated with complement deposition (e.g., C3 glomerulopathy)
Validation Data