Cfh KO
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Strain Description
The Cfh KO mouse is a gene knockout model created using gene-editing techniques to knock out the Exon 2~3 of the Cfh gene (the homolog of the human CFH gene) in mice. This model can be used for research into the pathogenic mechanisms of diseases such as age-related macular degeneration, atypical hemolytic uremic syndrome, C3 glomerulopathy, and Type II membranoproliferative glomerulonephritis, as well as for the development of related treatment methods.
Application Area
Research on the regulatory mechanisms of the complement system
Atypical hemolytic uremic syndrome (aHUS) pathogenesis research and treatment drug assessment
Age-related macular degeneration (AMD) pathological model construction and intervention strategy development
Mechanistic exploration of complement overactivation in autoimmune diseases
Pathological research of kidney diseases associated with complement deposition (e.g., C3 glomerulopathy)
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