B6-hB7-H4 (hVTCN1)
Product Type
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Genotype
Sex
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Basic Information
Model Name
B6-hB7-H4 (hVTCN1)
Product ID
C001806
Gene Name
Background
C57BL/6NCya
Gene Alias
B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291
Classification
Immune Target Humanized Models,Full-Gene Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hB7-H4 (hVTCN1) mice (Catalog C001806) were purchased from Cyagen.”
Strain Description
The B6-hB7-H4 (hVTCN1) mouse is a humanized model, constructed by replacing the partial extracellular domain (aa.35~255) of the endogenous mouse Vtcn1 gene with the partial extracellular domain (aa.35~255) of the human VTCN1 gene. B6-hB7-H4 (hVTCN1) mice can be used for research into the pathogenesis of various cancers, as well as autoimmune and inflammatory diseases. They are also useful for the screening, development, and safety evaluation of VTCN1-targeted drugs.
Application Area
VTCN1-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of certain cancers
Research on the pathological mechanisms and therapeutic approaches of autoimmune and inflammatory diseases like rheumatoid arthritis (RA) and type 1 diabetes
Validation Data