B6-hCCR8
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Genotype
Sex
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Basic Information
Model Name
B6-hCCR8
Product ID
C001808
Gene Name
Background
C57BL/6NCya
Gene Alias
CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8
Classification
Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hCCR8 mice (Catalog C001808) were purchased from Cyagen.”
Strain Description
The B6-hCCR8 mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Ccr8 gene with the coding sequences of the human CCR8 gene. B6-hCCR8 mice can be used for research into the pathogenesis of allergic disorders, various cancers, chronic inflammatory conditions, and HIV-1 infection, as well as for the screening, development, and safety evaluation of CCR8-targeted drugs.
Application Area
CCR8-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of allergic disorders (like asthma and atopic dermatitis)
Research on the pathological mechanisms and therapeutic approaches of various cancers (e.g., malignant melanoma, hepatocellular carcinoma, cutaneous T-cell lymphomas)
Research on the pathological mechanisms and therapeutic approaches of chronic inflammatory conditions such as chronic obstructive pulmonary disease (COPD) and potentially multiple sclerosis (MS)
Research on HIV-1 infection
Validation Data