B6-hOSM
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hOSM
Product ID
C001815
Gene Name
Background
C57BL/6NCya
Gene Alias
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Classification
Cytokine Humanized Models,Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hOSM mice (Catalog C001815) were purchased from Cyagen.”
Strain Description
The B6-hOSM mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Osm gene with the coding sequences of the human OSM gene. B6-hOSM mice can be used for research into the pathogenesis of inflammatory conditions such as arthritis (rheumatoid and osteoarthritis), inflammatory bowel disease, lung and skin diseases (e.g., psoriasis, asthma), cardiovascular diseases (e.g., atherosclerosis), liver diseases (e.g., fibrosis), various cancers, and bone marrow failure syndromes, as well as for the screening, development, and safety evaluation of OSM-targeted drugs.
Application Area
OSM-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of inflammatory diseases, including rheumatoid arthritis (RA), osteoarthritis, and inflammatory bowel disease (IBD)
Research on cardiovascular diseases, including atherosclerosis
Research on liver diseases, including fibrosis
Research on various cancers
Research on the pathological mechanisms and therapeutic approaches of bone marrow failure syndromes
Validation Data