The B6-hC5 mouse model is a humanized model of the Hc gene, with the mouse Hc gene homologous to the human C5 gene. Using gene-editing technology, the mouse Hc gene was replaced with the human C5 gene while retaining the mouse signal peptide; the humanized region also includes the 3’ UTR. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also generate mutation models based on this strain and provide customized services.