Alpl KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Alpl KO
Product ID
C001849
Gene Name
Background
C57BL/6JCya
Gene Alias
ALP; Akp2; TNAP; Akp-2; APTNAP; TNSALP
Classification
Metabolic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “Alpl KO mice (Catalog C001849) were purchased from Cyagen.”
Strain Description
The Alpl KO mouse is a knockout (KO) model in which the exon 3~4 of the Alpl gene (homologous to the human ALPL gene) has been deleted via gene-editing technology. Preliminary validation data indicate that homozygous Alpl KO mice have a short lifespan, dying within four weeks when given a specialized diet. If they are not provided with this dietary support, no surviving homozygous individuals are obtained. This model can be used to study the pathogenic mechanisms of diseases such as hypophosphatasia (HPP), osteoporosis, and osteosarcoma (OS), and to provide a basis for developing related therapeutic strategies.
Application Area
Research on hypophosphatasia (HPP)
Research on osteoporosis
Research on osteosarcoma (OS)
Validation Data