B6-huMSLN
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-huMSLN
Product ID
C001856
Gene Name
Background
C57BL/6NCya
Gene Alias
MPF; SMRP
Classification
Tumor Target Humanized Models,Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-huMSLN mice (Catalog C001856) were purchased from Cyagen.”
Strain Description
The B6-huMSLN mouse model was generated by replacing sequences from the ATG start codon to the TGA stop codon of the endogenous mouse Msln gene with the sequences from the ATG start codon to the TGA stop codon of the human MSLN gene. This model can be used to study the pathological mechanisms and therapeutic approaches for several cancers, including malignant mesothelioma, ovarian cancer, pancreatic cancer, and certain types of lung cancer, as well as for the development of MSLN-targeted drugs.
Application Area
MSLN-targeted drug screening, development, and evaluation
Research on pathological mechanisms and therapeutic approaches for several cancers
Validation Data