B6-huTMPRSS6
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Genotype
Sex
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Basic Information
Model Name
B6-huTMPRSS6
Product ID
C001864
Gene Name
Background
C57BL/6NCya
Gene Alias
MT2; IRIDA
Classification
Full-Gene Humanized Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-huTMPRSS6 mice (Catalog C001864) were purchased from Cyagen.”
Strain Description
The B6-huTMPRSS6 mouse model was generated by replacing the sequences from ~6.5 kb upstream of exon 1 to 3’UTR of the mouse Tmprss6 gene with the sequences from ~15 kb upstream of exon 1 to 3’UTR of the human TMPRSS6 gene. This model can be used to study the pathological mechanisms and therapeutic approaches for iron-refractory iron deficiency anemia (IRIDA), as well as for the development of TMPRSS6-targeted drugs.
Application Area
TMPRSS6-targeted drug screening, development, and evaluation
Research on pathological mechanisms and therapeutic approaches for iron-refractory iron deficiency anemia (IRIDA)
Validation Data