B6-hIL7 Mouse
Product Name
B6-hIL7 Mouse
Product ID
C001870
Strain Name
C57BL/6NCya-Il7tm1(hIL7)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “B6-hIL7 Mouse (Catalog C001870) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
IL7
Gene Alias
IL-7
NCBI ID
Chromosome
Chr 8 (Human)
MGI ID
Datasheet
Strain Description
The IL7 gene encodes the cytokine Interleukin-7 (IL-7), a secreted protein crucial for the development, survival, and homeostasis of B and T lymphocytes, as well as innate lymphoid cells (ILCs) [1]. Gene expression of IL7 is primarily observed in stromal cells of primary and secondary lymphoid organs like the bone marrow and thymus, as well as in non-marrow-derived epithelial cells in various peripheral tissues, including the intestine and skin. The function of the encoded IL-7 protein is to bind to its receptor (composed of the IL-7R α-chain and the common γc-chain) on lymphoid progenitor and mature cells, activating the JAK-STAT signaling pathway to promote cell proliferation and survival [2]. Dysregulation of the IL-7/IL-7R pathway is linked to several associated diseases, most notably severe combined immunodeficiency (SCID) due to T-cell deficiency, as well as various autoimmune diseases (e.g., Multiple Sclerosis, Rheumatoid Arthritis, Type 1 Diabetes) and lymphoid malignancies like Acute Lymphoblastic Leukemia (ALL) [3].
B6-hIL7 mouse is a humanized model generated using gene editing technology, in which the coding sequence of exon 1 is replaced with the Kozak-Human IL7 CDS-3'UTR of Mouse Il7-WPRE-BGH pA cassette. This model can be used for studying the pathological mechanisms and therapeutic approaches of severe combined immunodeficiency (SCID), various autoimmune diseases, and lymphoid malignancies, as well as for the development of IL7-targeted drugs.
Reference
Nagasawa M, Spits H, Ros XR. Innate Lymphoid Cells (ILCs): Cytokine Hubs Regulating Immunity and Tissue Homeostasis. Cold Spring Harb Perspect Biol. 2018 Dec 3;10(12):a030304.
Henriques CM, Rino J, Nibbs RJ, Graham GJ, Barata JT. IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells. Blood. 2010 Apr 22;115(16):3269-77.
Zeng Z, Mao H, Lei Q, He Y. IL-7 in autoimmune diseases: mechanisms and therapeutic potential. Front Immunol. 2025 Apr 17;16:1545760.
Strain Strategy
The coding sequence of exon 1 was replaced with the Kozak-Human IL7 CDS-3'UTR of Mouse Il7-WPRE-BGH pA cassette.
Figure 1. Gene editing strategy of B6-hIL7 mice.
Application Area
IL7-targeted drug screening, development, and evaluation;
Research on severe combined immunodeficiency (SCID);
Research on the pathological mechanisms and therapeutic approaches of various autoimmune diseases (e.g., Multiple Sclerosis, Rheumatoid Arthritis, Type 1 Diabetes);
Research on the pathological mechanisms and therapeutic approaches of lymphoid malignancies like Acute Lymphoblastic Leukemia (ALL).
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