huACVR2A Mouse
Product Name
huACVR2A Mouse
Product ID
C001903
Strain Name
C57BL/6NCya-Acvr2atm1(hACVR2A)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “huACVR2A Mouse (Catalog C001903) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
ACVR2A
Gene Alias
ACVR2, ACTRII
NCBI ID
Chromosome
Chr 2 (Human)
MGI ID
Datasheet
Strain Description
The ACVR2A (Activin A Receptor Type 2A) gene encodes a transmembrane serine-threonine kinase receptor that functions as a Type II receptor in the Transforming Growth Factor-beta (TGF-beta) superfamily signaling pathway. The encoded protein is primarily involved in ligand-binding (e.g., activins A and B, inhibin A, and specific bone morphogenetic proteins like BMP-7), forming heterodimeric complexes with Type I receptors to initiate downstream signaling cascades, often involving SMAD transcription factors, which regulate cell growth, differentiation, and apoptosis [1]. Gene expression is observed in numerous tissues, including high levels in the placenta, endometrium, testes, prostate, ovary, skeletal muscle, heart, and neural tissues such as the hypothalamus and cerebral cortex, underscoring its diverse biological roles. Dysfunction or polymorphisms in ACVR2A have been implicated in several diseases, notably preeclampsia (a severe pregnancy disorder associated with decreased placental ACVR2A expression and impaired trophoblast invasion) and various cancers, particularly colorectal and gastric cancers with microsatellite instability, where loss of receptor expression contributes to tumor pathogenesis [2-3].
huACVR2A mouse is a humanized model generated using gene editing technology, in which the sequences from the ATG start codon to partial 3’UTR (downstream of mouse Orc4 3’UTR) of mouse Acvr2a gene are replaced with the sequences from ATG start codon to downstream of 3’UTR of human ACVR2A gene. This model can be used for research related to malignant tumors such as colorectal cancer and gastric cancer, bone and cartilage development diseases, reproductive system and gonad development, as well as the development of ACVR2A-targeted drugs.
Reference
Yang S, Liu H, Hu J, Chen B, An W, Song X, Yang Y, He F. ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression. Elife. 2025 May 30;14:RP101236.
Honarpour A, Majd A, Sadeghi H, Jamaldini S, Rahimi M, Kazemzadeh P, Mirfakhraie R. The First Evidence for the Role of ACVR2A Gene Fetal Genotype in Preeclampsia Susceptibility. Mol Genet Genomic Med. 2025 Feb;13(2):e70069.
Yamamoto H, Imai K. Microsatellite instability: an update. Arch Toxicol. 2015 Jun;89(6):899-921.
Strain Strategy
The sequences from the ATG start codon to partial 3’UTR (downstream of mouse Orc4 3’UTR) of mouse Acvr2a gene were replaced with the sequences from the ATG start codon to downstream of 3’UTR of human ACVR2A gene.
Figure 1. Gene editing strategy of huACVR2A mice.
Application Area
Screening, development, and preclinical evaluation of ACVR2A-targeted drugs;
Research on the pathological mechanisms and therapeutic approaches of malignant tumors such as colorectal cancer and gastric cancer;
Research on the mechanisms of bone and cartilage development diseases;
Research on the reproductive system and gonad development.
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