huIL15RA Mouse
Product Name
huIL15RA Mouse
Product ID
C001981
Strain Name
C57BL/6NCya-Il15ratm1(hIL15RA)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “huIL15RA Mouse (Catalog C001981) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
IL15RA
Gene Alias
CD215
NCBI ID
Chromosome
Chr 10 (Human)
MGI ID
Datasheet
Strain Description
The IL15RA gene, located on chromosome 10, encodes the interleukin-15 receptor subunit alpha, a high-affinity binding protein essential for mediating the biological activities of IL-15. This gene is widely expressed across various tissues, including lymphoid organs (thymus and spleen), the gastrointestinal tract, skeletal muscle, and liver, as well as by specific cell types such as monocytes, dendritic cells, and activated T and B cells. The encoded protein is unique for its "cis" and "trans-presentation" mechanisms, where it binds IL-15 within the endoplasmic reticulum and transports it to the cell surface to signal to neighboring cells expressing IL-2/IL-15 receptor β- and γ-chains. This function is critical for the proliferation and survival of Natural Killer (NK) cells and memory CD8⁺ T cells, thereby regulating innate and adaptive immune homeostasis [1]. Pathologically, dysregulation of IL15RA is associated with various autoimmune diseases like rheumatoid arthritis (RA) and psoriasis, as well as inflammatory bowel diseases (IBD) and several hematological malignancies [2].
The huIL15RA mouse is a humanized model constructed through gene-editing technology, in which the mouse Il15ra endogenous extracellular domain is replaced with the human IL15RA extracellular domain. This model can be used for research into the pathological mechanisms and related therapeutic approaches for autoimmune diseases, inflammatory diseases, and various hematologic malignancies, as well as for screening, development, and preclinical evaluation of IL15RA-targeted drugs.
Reference
Guo Y, Luan L, Patil NK, Sherwood ER. Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent. Cytokine Growth Factor Rev. 2017 Dec;38:10-21.
Meghnem D, Maillasson M, Barbieux I, Morisseau S, Keita D, Jacques Y, Quéméner A, Mortier E. Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation. Front Immunol. 2022 May 3;13:886213.
Strain Strategy
The mouse Il15ra endogenous extracellular domain was replaced with the human IL15RA extracellular domain.
Figure 1. Gene editing strategy of huIL15RA mice.
Application Area
Screening, development, and preclinical evaluation of IL15RA-targeted drugs;
Research on the pathogenic mechanisms and related treatment methods of various autoimmune diseases, such as rheumatoid arthritis (RA) and psoriasis;
Research on the pathogenic mechanisms and related treatment methods of inflammatory diseases, such as inflammatory bowel disease (IBD);
Research on the pathogenic mechanisms and related treatment methods of various hematological malignancies.
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