hCDH17 Mouse
Product Name
hCDH17 Mouse
Product ID
C002045
Strain Name
C57BL/6NCya-Cdh17tm1(hCDH17)/Cya
Backgroud
C57BL/6NCya
Status
When using this mouse strain in a publication, please cite “hCDH17 Mouse (Catalog C002045) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Gene Name
CDH17
Gene Alias
HPT1, CDH16, HPT-1
NCBI ID
Chromosome
Chr 8 (Human)
MGI ID
Datasheet
Strain Description
CDH17 (Cadherin 17), a member of the cadherin superfamily encoded by the CDH17 gene, is also known as liver-intestine cadherin (LI-cadherin). It is primarily expressed in the epithelial cells of the digestive tract, such as the small intestine and colon, and plays a crucial role in cell adhesion, maintenance of the epithelial barrier, and intestinal tissue homeostasis [1-2]. Studies have shown that CDH17 is abnormally overexpressed in various gastrointestinal tumors, including gastric, colorectal, pancreatic, and hepatocellular carcinomas. Its expression is closely associated with tumor proliferation, invasion, metastasis, and poor prognosis, making it a promising potential therapeutic target [2-4]. Currently, research involving CDH17-targeting monoclonal antibodies, antibody-drug conjugates (ADCs), and CAR-T/CAR-NK cell therapies is underway to explore their potential in the targeted treatment of gastrointestinal cancers [3-5].
The hCDH17 mouse is a humanized model generated via gene editing. In this model, the region from aa.28 in exon 3 to partial intron 3 of the mouse Cdh17 was replaced with Mature Chimeric CDH17 CDS-3’UTR of the mouse Cdh17-WPRE-BGH pA cassette. The murine signal peptide was preserved. This model is suitable for evaluating the in vivo efficacy and safety of CDH17-targeting monoclonal antibodies, ADCs, and CAR-T/CAR-NK cell therapies. It is also applicable for research into the mechanisms of gastrointestinal tumor development, the tumor immune microenvironment, and combination therapeutic strategies.
Reference
Berndorff D, Gessner R, Kreft B, et al. Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine. J Cell Biol. 1994, 125(6):1353-1369.
Wang J, Yu JC, Kang WM, et al. The predictive effect of cadherin-17 on lymph node micrometastasis in pN0 gastric cancer. Ann Surg Oncol. 2012, 19(5):1529-1534.
Bartolomé RA, Barderas R, Torres S, et al. Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis. Oncogene. 2014, 33(13):1658-1669.
Su MC, Yuan RH, Lin CY, et al. Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. Mod Pathol. 2008, 21(11):1379-1386.
Senoo A, Hagiwara S, Wang L, et al. Development of anti-CDH17 antibody-drug conjugate for gastrointestinal cancers. Mol Cancer Ther. 2021, 20(12):2320-2331.
Strain Strategy
The region from aa.28 in exon 3 to partial intron 3 of the mouse Cdh17 was replaced with Mature Chimeric CDH17 CDS-3’UTR of the mouse Cdh17-WPRE-BGH pA cassette. The murine signal peptide was preserved.
*Mature Chimeric CDH17 CDS: Human CDH17 Extracellular domain-Mouse Cdh17 Transmembrane and Cytoplasmic domain.
Figure 1. Gene targeting strategy for hCDH17 mice.
Application Area
Investigation into the mechanisms of gastrointestinal tumorigenesis and progression;
Development and safety evaluation of CDH17-targeted therapeutics;
Research on tumor immunotherapy and combination treatment strategies.
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