SD-hGHR rats are a humanized model generated using gene editing technology, in which the chimeric human GHR CDS encoding the human-rat chimeric GHR protein and its downstream human 3’UTR sequence were integrated into the rat GHR gene locus. In this model, the chimeric human GHR CDS is composed of the following sequences: the sequence encoding the signal peptide and extracellular domain of the human GHR protein, and the sequence encoding the transmembrane and intracellular domains of the rat GHR protein. Homozygous SD-hGHR rats are viable and fertile, and can be used for studying the pathological mechanisms and therapeutic approaches for endocrine diseases and specific cancers, as well as for the screening, research and development, and preclinical efficacy and safety evaluation of GHR-targeted drugs.