NKG-Kit*V831M
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Strain Description
The NKG-Kit*V831M mouse strain is generated by introducing the W41 mutation (V831M) into the KIT gene of the NKG mouse. Compared to standard NKG mice, these mice eliminate the need for irradiation during HSC reconstitution, thereby avoiding the deleterious effects of irradiation on the hematopoietic, gastrointestinal, and nervous systems. This feature renders NKG-Kit*V831M mice an invaluable tool for developing and evaluating tumor immunotherapies and conducting drug efficacy assessments.
Application Area
Construction of humanized mouse models for the immune system
Studies on the human immune and hematopoietic systems
Xenotransplantation of human cell lines (CDX) for drug screening and efficacy evaluation
Xenotransplantation of patient-derived tumor tissues (PDX) for drug screening and efficacy evaluation
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