C57BL/6JCya-Synj1em1flox/Cya
Common Name:
Synj1-flox
Product ID:
S-CKO-00357
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Synj1-flox
Strain ID
CKOCMP-104015-Synj1-B6J-VA
Gene Name
Product ID
S-CKO-00357
Gene Alias
A930006D20Rik; mKIAA0910
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
16
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Synj1em1flox/Cya mice (Catalog S-CKO-00357) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000121759
NCBI RefSeq
NM_001164483
Target Region
Exon 4
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Synj1, short for Synaptojanin1, is a phosphoinositide phosphatase with dual SAC1 and 5'-phosphatase enzymatic activities. It is crucial for regulating phospholipid signaling and participates in synaptic vesicle (SV) recycling in neurons [2].
In mouse models, Synj1 heterozygous deletion (Synj1+/-) leads to PD-like pathologies. Male Synj1+/- mice show age-dependent motor function abnormalities, alpha-synuclein accumulation, impaired autophagy and dopaminergic terminal degeneration. Elevated 5'-phosphatase substrate, PI(4,5)P2, is found in midbrain neurons of Synj1+/- mice, and pharmacological elevation of membrane PI(4,5)P2 impairs SV endocytosis, especially in midbrain neurons, exacerbating SV trafficking defects [2]. Overexpression of SYNJ1 in hSNCA*A53T-Tg and MPTP-induced mice can rescue motor functions by upregulating TSP-1 expression, which is involved in the extracellular matrix pathways [1].
In conclusion, Synj1 is essential for synaptic vesicle recycling and phospholipid signaling in neurons. Studies on Synj1 KO/CKO mouse models have revealed its significant role in Parkinson's disease, showing that its deficiency can cause PD-like pathologies, while its overexpression may have a protective effect, providing potential therapeutic targets for PD [1,2].
References:
1. Tian, Yueqin, Yi, Shang, Guo, Wanyun, Xie, Haiting, Gao, Xiaoya. 2023. SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression. In Behavioural brain research, 452, 114569. doi:10.1016/j.bbr.2023.114569. https://pubmed.ncbi.nlm.nih.gov/37419331/
2. Pan, Ping-Yue, Sheehan, Patricia, Wang, Qian, Cai, Dongming, Yue, Zhenyu. . Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice. In Human molecular genetics, 29, 2300-2312. doi:10.1093/hmg/ddaa080. https://pubmed.ncbi.nlm.nih.gov/32356558/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen