C57BL/6JCya-Taar1em1flox/Cya
Common Name:
Taar1-flox
Product ID:
S-CKO-00917
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Taar1-flox
Strain ID
CKOCMP-111174-Taar1-B6J-VA
Gene Name
Product ID
S-CKO-00917
Gene Alias
Tar1; Trar1; taR-1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Taar1em1flox/Cya mice (Catalog S-CKO-00917) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000051532
NCBI RefSeq
NM_053205
Target Region
Exon 1
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Trace amine-associated receptor 1 (TAAR1) senses endogenous amine-containing metabolites (EAMs) and is involved in mediating diverse psychological functions [1]. It modulates monoamine transmission, especially dopamine, and is widely distributed in the monoaminergic system in the mammalian brain, including areas like the ventral tegmental area and substantia nigra [3]. TAAR1 is considered a promising target for treating psychiatric disorders such as schizophrenia, substance use disorders, and sleep, depression, and anxiety-related disorders [3].
Studies in Taar1 knockout (TAAR1-KO) rodents show that TAAR1 agonism inhibits midbrain dopaminergic and serotonergic activity, and enhances prefrontal glutamatergic function [2]. In preclinical models of psychostimulant addiction, activation of TAAR1 attenuated while knockout of TAAR1 potentiated psychostimulant abuse-related behaviors [5]. These suggest that TAAR1 negatively modulates monoamine-related activities and behaviors [4].
In conclusion, TAAR1 plays a crucial role in modulating monoamine transmission and is involved in various psychiatric disorders. The use of TAAR1-KO mouse models has revealed its role in regulating midbrain neurotransmitter activities and psychostimulant-related behaviors, providing valuable insights for developing treatments for schizophrenia and substance use disorders.
References：
1. Shang, Pan, Rong, Naikang, Jiang, Jing-Jing, Yang, Fan, Sun, Jin-Peng. 2023. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. In Cell, 186, 5347-5362.e24. doi:10.1016/j.cell.2023.10.014. https://pubmed.ncbi.nlm.nih.gov/37963465/
2. Halff, Els F, Rutigliano, Grazia, Garcia-Hidalgo, Anna, Howes, Oliver D. 2022. Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders. In Trends in neurosciences, 46, 60-74. doi:10.1016/j.tins.2022.10.010. https://pubmed.ncbi.nlm.nih.gov/36369028/
3. Liu, Jianfeng, Wu, Ruyan, Li, Jun-Xu. 2023. TAAR1 as an emerging target for the treatment of psychiatric disorders. In Pharmacology & therapeutics, 253, 108580. doi:10.1016/j.pharmthera.2023.108580. https://pubmed.ncbi.nlm.nih.gov/38142862/
4. Liu, Jian-Feng, Li, Jun-Xu. 2018. TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg. In Frontiers in pharmacology, 9, 279. doi:10.3389/fphar.2018.00279. https://pubmed.ncbi.nlm.nih.gov/29636691/
5. Liu, Jianfeng, Wu, Ruyan, Li, Jun-Xu. 2020. TAAR1 and Psychostimulant Addiction. In Cellular and molecular neurobiology, 40, 229-238. doi:10.1007/s10571-020-00792-8. https://pubmed.ncbi.nlm.nih.gov/31974906/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen