C57BL/6JCya-Adra1aem1flox/Cya
Common Name:
Adra1a-flox
Product ID:
S-CKO-01078
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Adra1a-flox
Strain ID
CKOCMP-11549-Adra1a-B6J-VA
Gene Name
Product ID
S-CKO-01078
Gene Alias
Adra1c
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
14
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Adra1aem1flox/Cya mice (Catalog S-CKO-01078) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000054661
NCBI RefSeq
NM_013461
Target Region
Exon 2
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
Adra1a, also known as the alpha-1A adrenergic receptor, is a crucial component in the adrenergic signaling pathway. It is involved in multiple physiological processes. Noradrenaline-induced ADRA1A-Gαq signalling promotes adipocyte thermogenesis through the effector proteins of the futile creatine cycle, creatine kinase B and tissue-non-specific alkaline phosphatase, highlighting its role in energy metabolism [1].
In a pregnancy-associated hypertensive (PAH) mouse model, Adra1a -deficient PAH mice exhibited more severe cardiac hypertrophy than PAH mice, suggesting that changes in Adra1a expression are involved in progressive cardiac hypertrophy in PAH mice as Adra1a levels are regulated by the renin-angiotensin system [2].
In summary, Adra1a plays essential roles in adipocyte thermogenesis and cardiac hypertrophy regulation. Gene-knockout mouse models, like the Adra1a -deficient mice in the PAH model, have provided valuable insights into its functions in disease-related biological processes, especially in energy metabolism and heart-related diseases.
References:
1. Rahbani, Janane F, Scholtes, Charlotte, Lagarde, Damien M, Giguère, Vincent, Kazak, Lawrence. 2022. ADRA1A-Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP. In Nature metabolism, 4, 1459-1473. doi:10.1038/s42255-022-00667-w. https://pubmed.ncbi.nlm.nih.gov/36344764/
2. Kim, Jun-Dal, Kwon, Chulwon, Nakamura, Kanako, Nakagawa, Yoshimi, Fukamizu, Akiyoshi. 2023. Increased angiotensin II coupled with decreased Adra1a expression enhances cardiac hypertrophy in pregnancy-associated hypertensive mice. In The Journal of biological chemistry, 299, 102964. doi:10.1016/j.jbc.2023.102964. https://pubmed.ncbi.nlm.nih.gov/36736425/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen