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C57BL/6JCya-Agerem1flox/Cya
Common Name:
Ager-flox
Product ID:
S-CKO-01095
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Ager-flox
Strain ID
CKOCMP-11596-Ager-B6J-VA
Gene Name
Ager
Product ID
S-CKO-01095
Gene Alias
RAGE
Background
C57BL/6JCya
NCBI ID
11596
Modification
Conditional knockout
Chromosome
17
Phenotype
MGI:893592
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Agerem1flox/Cya mice (Catalog S-CKO-01095) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000015596
NCBI RefSeq
NM_007425
Target Region
Exon 1~7
Size of Effective Region
~1.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
AGER, also known as the receptor for advanced glycation end-products (RAGE), is a cell-surface transmembrane multiligand receptor encoded by the AGER gene. It is mainly expressed in the lung and is involved in multiple pathways such as NFκB, Akt, p38, and MAP kinases, which initiate and perpetuate a pro-inflammatory state [2].

In pancreatic ductal adenocarcinoma (PDAC) driven by the KRAS-G12D mutation, up-regulation of AGER in cancer cells instigates macropinocytosis, facilitating the internalization of serum albumin and subsequent amino acid generation for antioxidant glutathione synthesis, leading to resistance to the KRAS-G12D inhibitor MRTX1133 [1].

In sepsis, AGER-mediated lipid peroxidation drives caspase-11 inflammasome activation in macrophages, and inhibition of the AGER-ALOX5 pathway or depletion of AGER in myeloid cells protects against lipopolysaccharide-induced septic death in poly(I:C)-primed mice [3].

In cervical cancer, blockage of AGER with siRNAs suppresses proliferation, stimulates apoptosis, and inhibits migration, while overexpression of AGER has the opposite effects, suggesting it functions as a tumor promoter [4].

In juvenile idiopathic arthritis, the homozygous AA rs1035798 genotype of the AGER gene is a risk factor, and allele A is also associated with the disease as well as with the articular syndrome of non-autoimmune etiology [5].

In conclusion, AGER plays crucial roles in various biological processes and disease conditions. Its functions in inflammation, apoptosis, immunity, and cancer progression are revealed through different research models. The study of AGER in gene knockout or conditional knockout mouse models, as well as other functional studies, provides insights into the molecular mechanisms underlying diseases like PDAC, sepsis, cervical cancer, and juvenile idiopathic arthritis, which may help develop new therapeutic strategies.

References:
1. Li, Changfeng, Liu, Yuanda, Liu, Chang, Tang, Daolin, Kang, Rui. 2025. AGER-dependent macropinocytosis drives resistance to KRAS-G12D-targeted therapy in advanced pancreatic cancer. In Science translational medicine, 17, eadp4986. doi:10.1126/scitranslmed.adp4986. https://pubmed.ncbi.nlm.nih.gov/39879317/
2. Serveaux-Dancer, Marine, Jabaudon, Matthieu, Creveaux, Isabelle, Blanchon, Loïc, Sapin, Vincent. 2019. Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism. In Disease markers, 2019, 2067353. doi:10.1155/2019/2067353. https://pubmed.ncbi.nlm.nih.gov/30863465/
3. Chen, Ruochan, Zhu, Shan, Zeng, Ling, Tang, Daolin, Kang, Rui. 2019. AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis. In Frontiers in immunology, 10, 1904. doi:10.3389/fimmu.2019.01904. https://pubmed.ncbi.nlm.nih.gov/31440260/
4. Zhu, Xuejie, Zhou, Lulu, Li, Ruyi, Shen, Zongji, Zhu, Haiyan. 2018. AGER promotes proliferation and migration in cervical cancer. In Bioscience reports, 38, . doi:10.1042/BSR20171329. https://pubmed.ncbi.nlm.nih.gov/29298878/
5. Bakutenko, Ivan Yurievich, Haurylchyk, Irena Dmitrievna, Sechko, Elena Vladimirovna, Sukalo, Alexander Vasil'evich, Ryabokon, Nadezhda Ivanovna. 2021. AGER gene variant as a risk factor for juvenile idiopathic arthritis. In The journal of gene medicine, 24, e3399. doi:10.1002/jgm.3399. https://pubmed.ncbi.nlm.nih.gov/34806241/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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