C57BL/6JCya-Fgfrl1em1flox/Cya
Common Name
Fgfrl1-flox
Product ID
S-CKO-01136
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-116701-Fgfrl1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Fgfrl1-flox Mouse (Catalog S-CKO-01136) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Fgfrl1-flox
Strain ID
CKOCMP-116701-Fgfrl1-B6J-VA
Gene Name
Product ID
S-CKO-01136
Gene Alias
FGFR5, FGFR5beta, FGFR5gamma
Background
C57BL/6JCya
Gene Full Name
fibroblast growth factor receptor-like 1
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 5 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000013633
NCBI Transcript ID
NM_054071
Target Region
Exon 3~7
Size of Effective Region
~4.7 kb
Overview of Gene Research
Fgfrl1, or fibroblast growth factor receptor like 1, is the fifth member of the FGFR family. It contains three extracellular Ig-like domains, lacks the protein tyrosine kinase domain, and has a short intracellular tail with a histidine-rich motif. Fgfrl1 binds to FGF ligands and heparin, and is involved in the FGF signaling system, playing important roles in cell proliferation (negative effect), cell differentiation (positive effect), and is crucial for organ development [1].
Gene-targeted deletion in mice shows that Fgfrl1-deficient mice die perinatally due to diaphragm alterations and bilateral kidney agenesis, suggesting its essential role in kidney development [1]. Mice lacking the Ig2 or Ig3 domain of Fgfrl1 die within 24 hours after birth, with Ig3-deficient mice completely lacking metanephric kidneys, indicating these domains' importance in nephrogenesis [2]. In a human patient, a frameshift mutation in Fgfrl1 led to craniosynostosis, highlighting its role in bone formation [1].
In conclusion, Fgfrl1 is essential for kidney development and bone formation as revealed by mouse models and human case. The study of Fgfrl1 in KO mouse models contributes to our understanding of congenital kidney and bone-related diseases, providing insights into the underlying molecular mechanisms and potential therapeutic targets.
References：
1. Trueb, Beat. 2010. Biology of FGFRL1, the fifth fibroblast growth factor receptor. In Cellular and molecular life sciences : CMLS, 68, 951-64. doi:10.1007/s00018-010-0576-3. https://pubmed.ncbi.nlm.nih.gov/21080029/
2. Gerber, Simon D, Beauchamp, Philippe, Zhuang, Lei, Villiger, Peter M, Trueb, Beat. 2020. Functional domains of the FgfrL1 receptor. In Developmental biology, 461, 43-54. doi:10.1016/j.ydbio.2020.01.003. https://pubmed.ncbi.nlm.nih.gov/31923383/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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