Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Casrem1flox/Cya
Common Name:
Casr-flox
Product ID:
S-CKO-01556
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Casr-flox
Strain ID
CKOCMP-12374-Casr-B6J-VA
Gene Name
Casr
Product ID
S-CKO-01556
Gene Alias
CaR; Gprc2a
Background
C57BL/6JCya
NCBI ID
12374
Modification
Conditional knockout
Chromosome
16
Phenotype
MGI:1351351
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Casrem1flox/Cya mice (Catalog S-CKO-01556) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000063597
NCBI RefSeq
NM_013803
Target Region
Exon 3
Size of Effective Region
~2.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
CaSR, the calcium-sensing receptor, is a class-C G protein-coupled receptor. It plays a pivotal role in regulating calcium homeostasis by sensing extracellular Ca2+ concentration changes. It is also involved in various other cellular processes such as gene transcription, cell proliferation, differentiation, apoptosis, muscle contraction, and neuronal transmission. The CaSR-mediated intracellular Ca2+ signaling is part of key biological pathways [2].

In conditional and global CaSR knockout mice, colonic epithelia showed increased proliferation with enhanced Wnt/β-catenin signaling, indicating that CaSR negatively modulates colonic epithelial growth [3]. In breast cancer, CaSR acts as an oncoprotein and drives the pathogenesis of skeletal metastases. Understanding the CaSR signaling in this context could lead to novel therapeutic interventions for metastatic breast cancer [1,5]. Mutations in the CASR gene cause autosomal dominant hypocalcemia type 1 (ADH1), characterized by hypocalcemia, low parathyroid hormone levels, and high urinary calcium [4].

In conclusion, CaSR is crucial for calcium homeostasis and various cellular functions. Gene knockout mouse models have revealed its role in colonic epithelial growth regulation and in the pathogenesis of breast cancer bone metastases and ADH1. Research on CaSR provides insights into the molecular basis of these disease conditions and may facilitate the development of targeted therapeutic agents.

References:
1. Das, Souvik, Clézardin, Philippe, Kamel, Said, Brazier, Michel, Mentaverri, Romuald. 2020. The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases. In Frontiers in oncology, 10, 69. doi:10.3389/fonc.2020.00069. https://pubmed.ncbi.nlm.nih.gov/32117726/
2. Tian, Li, Andrews, Corey, Yan, Qiuyun, Yang, Jenny J. 2024. Molecular regulation of calcium-sensing receptor (CaSR)-mediated signaling. In Chronic diseases and translational medicine, 10, 167-194. doi:10.1002/cdt3.123. https://pubmed.ncbi.nlm.nih.gov/39027195/
3. Macleod, R John. 2013. CaSR function in the intestine: Hormone secretion, electrolyte absorption and secretion, paracrine non-canonical Wnt signaling and colonic crypt cell proliferation. In Best practice & research. Clinical endocrinology & metabolism, 27, 385-402. doi:10.1016/j.beem.2013.05.005. https://pubmed.ncbi.nlm.nih.gov/23856267/
4. Wu, Yingying, Zhang, Chao, Huang, Xiaojun, Liu, Shihua, Zhong, Ping. . Autosomal dominant hypocalcemia with a novel CASR mutation: a case study and literature review. In The Journal of international medical research, 50, 3000605221110489. doi:10.1177/03000605221110489. https://pubmed.ncbi.nlm.nih.gov/35818129/
5. Yang, Yanmei, Wang, Bin. 2018. PTH1R-CaSR Cross Talk: New Treatment Options for Breast Cancer Osteolytic Bone Metastases. In International journal of endocrinology, 2018, 7120979. doi:10.1155/2018/7120979. https://pubmed.ncbi.nlm.nih.gov/30151009/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest