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C57BL/6JCya-Cebpzem1flox/Cya
Common Name:
Cebpz-flox
Product ID:
S-CKO-01693
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Cebpz-flox
Strain ID
CKOCMP-12607-Cebpz-B6J-VA
Gene Name
Cebpz
Product ID
S-CKO-01693
Gene Alias
CBF2; Cbf
Background
C57BL/6JCya
NCBI ID
12607
Modification
Conditional knockout
Chromosome
17
Phenotype
MGI:109386
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cebpzem1flox/Cya mice (Catalog S-CKO-01693) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000024885
NCBI RefSeq
NM_001024806
Target Region
Exon 3~4
Size of Effective Region
~2.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cebpz, also known as CAATT-box binding protein, is involved in multiple biological processes. It has been associated with pathways related to ribosomal RNA (rRNA) processing, and is thought to play a role in maintaining the balance of cell differentiation and proliferation. Genetic models are valuable for studying its functions in different physiological and pathological conditions [3].

In glucocorticoid-associated osteonecrosis of the femoral head, exosomal miR-1a-3p from glucocorticoid-stimulated M1 macrophages promotes the adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by targeting Cebpz. Inhibiting miR-1a-3p expression mitigates the preferential adipogenic differentiation of BMSCs, suggesting Cebpz has a role in the pathogenesis of this disease [1]. In autophagy-dependent melanoma, Cebpz, as a component of the PERK-dependent endoplasmic reticulum (ER)-stress response, upregulates interleukin-24 (IL24) expression upon PIKFYVE inhibitor treatment, leading to cell death [2].

In conclusion, Cebpz is essential in processes like adipogenic differentiation and ER-stress response-mediated cell death. Studies using relevant models have revealed its significance in diseases such as glucocorticoid-associated osteonecrosis of the femoral head and autophagy-dependent melanoma, providing potential therapeutic targets for these conditions.

References:
1. Duan, Ping, Yu, Yong-Le, Cheng, Yan-Nan, Ji, Yan-Xiao, Pan, Zhen-Yu. 2024. Exosomal miR-1a-3p derived from glucocorticoid-stimulated M1 macrophages promotes the adipogenic differentiation of BMSCs in glucocorticoid-associated osteonecrosis of the femoral head by targeting Cebpz. In Journal of nanobiotechnology, 22, 648. doi:10.1186/s12951-024-02923-5. https://pubmed.ncbi.nlm.nih.gov/39438865/
2. Roy, Ajit, Chakraborty, Arup R, DePamphilis, Melvin L. 2024. PIKFYVE inhibitors trigger interleukin-24-dependent cell death of autophagy-dependent melanoma. In Molecular oncology, 18, 988-1011. doi:10.1002/1878-0261.13607. https://pubmed.ncbi.nlm.nih.gov/38414326/
3. Rambaldelli, Guglielmo, Manara, Valeria, Vutera Cuda, Andrea, Penzo, Marianna, Bellosta, Paola. 2025. From Flies to Humans: Conserved Roles of CEBPZ, NOC2L, and NOC3L in rRNA Processing and Tumorigenesis. In bioRxiv : the preprint server for biology, , . doi:10.1101/2025.01.11.632529. https://pubmed.ncbi.nlm.nih.gov/39868138/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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