C57BL/6JCya-Campem1flox/Cya
Common Name:
Camp-flox
Product ID:
S-CKO-01786
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Camp-flox
Strain ID
CKOCMP-12796-Camp-B6J-VA
Gene Name
Product ID
S-CKO-01786
Gene Alias
CAP18; CLP; Cnlp; Cramp; FALL39; MCLP
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Campem1flox/Cya mice (Catalog S-CKO-01786) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000112022
NCBI RefSeq
NM_009921.2
Target Region
Exon 2~4
Size of Effective Region
~2.3 bp
Detailed Document
Overview of Gene Research
Camp, short for cyclic adenosine monophosphate, is the first discovered second messenger. It plays pivotal roles in cell signaling, regulating numerous physiological and pathological processes. Camp mainly exerts its functions through the protein kinase A (PKA) pathway and downstream effectors like cAMP-responsive element binding protein (CREB). It can also phosphorylate kinases such as Raf, GSK3, and FAK. Camp is involved in various cellular activities including cell growth, migration, invasion, and metabolism [1].
Aberrant Camp-PKA signaling is associated with different types of human tumors. Depending on the tumor types and context, Camp signaling can have both tumor-suppressive and tumor-promoting roles. Small-molecule agents that inhibit adenylate cyclase and PKA, as well as Camp-elevating agents like forskolin, have shown potential in cancer therapy [1,2].
In conclusion, Camp is a crucial second messenger regulating a wide range of cellular functions. Its dysregulation is implicated in cancer, and understanding its role in tumorigenesis through functional studies, potentially including gene knockout (KO) or conditional knockout (CKO) mouse models in future research, may provide new therapeutic strategies for cancer treatment.
References:
1. Zhang, Hongying, Kong, Qingbin, Wang, Jiao, Jiang, Yangfu, Hua, Hui. 2020. Complex roles of cAMP-PKA-CREB signaling in cancer. In Experimental hematology & oncology, 9, 32. doi:10.1186/s40164-020-00191-1. https://pubmed.ncbi.nlm.nih.gov/33292604/
2. Zhang, Hongying, Liu, Yongliang, Liu, Jieya, Hua, Hui, Jiang, Yangfu. 2024. cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment. In Journal of hematology & oncology, 17, 5. doi:10.1186/s13045-024-01524-x. https://pubmed.ncbi.nlm.nih.gov/38233872/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen