Cyp2b19 is a cytochrome P450 enzyme that functions as an arachidonic acid monooxygenase. It is highly expressed in the outer, differentiated cell layers of mouse epidermis. It is involved in the arachidonic acid metabolism pathway, generating epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs), which play roles in epidermal cornification and other biological processes [1,2].

In mouse models, primary cultures of epidermal keratinocytes expressed native Cyp2b19. Differentiation led to up-regulation of Cyp2b19 mRNA, protein immunoreactivity, and levels of its product 11,12-EET. The temporal increase in cellular 11,12-EET from endogenous arachidonic acid during keratinocyte differentiation correlated with Cyp2b19 expression changes, suggesting it is the major source of epidermal EET formation [1]. Also, in the context of type 2 diabetes mellitus-induced gastroenteropathy in db/db mice, Cyp2b19 was among the major proteins associated with gastrointestinal injury, indicating its possible role in this disease-related condition [3].

In conclusion, Cyp2b19 is crucial for the production of EETs in the mouse epidermis, which is important for epidermal cornification. The findings from mouse models also hint at its potential involvement in type 2 diabetes-related gastroenteropathy. Understanding Cyp2b19's functions through these models can provide insights into epidermal biology and diabetes-associated gastrointestinal complications.