C57BL/6JCya-Engem1flox/Cya
Common Name:
Eng-flox
Product ID:
S-CKO-02203
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Eng-flox
Strain ID
CKOCMP-13805-Eng-B6J-VA
Gene Name
Product ID
S-CKO-02203
Gene Alias
CD105; Endo; S-endoglin
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Engem1flox/Cya mice (Catalog S-CKO-02203) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000009705
NCBI RefSeq
NM_007932
Target Region
Exon 2
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Eng, also known as Endoglin, is a key biomarker in liver cancer. It plays a crucial role in angiogenesis and is associated with immune responses in liver cancer. ENG promotes the differentiation of tumor cells into vascular endothelial cells and is a regulator of the formation of the tumor vasculature [1].
High expression of ENG in liver cancer is linked to more aggressive cancer characteristics and worse patient prognosis. Pathway enrichment and functional analyses have identified its significance in immune responses and angiogenesis. Additionally, HCC patients with elevated ENG levels respond well to sorafenib treatment [1].
In conclusion, ENG is an important biomarker in liver cancer, playing a vital role in angiogenesis and tumor cell differentiation. Understanding ENG's function through research can potentially help identify liver cancer patients who may benefit from targeted immunotherapies, contributing to advancements in liver cancer treatment strategies.
References：
1. Shi, Shangheng, Zhu, Cunle, Hu, Yue, Zhao, Jinxin, Xu, Qingguo. . ENG is a Biomarker of Prognosis and Angiogenesis in Liver Cancer, and Promotes the Differentiation of Tumor Cells into Vascular ECs. In Frontiers in bioscience (Landmark edition), 29, 315. doi:10.31083/j.fbl2909315. https://pubmed.ncbi.nlm.nih.gov/39344331/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen