C57BL/6JCya-Foxm1em1flox/Cya
Common Name:
Foxm1-flox
Product ID:
S-CKO-02442
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Foxm1-flox
Strain ID
CKOCMP-14235-Foxm1-B6J-VA
Gene Name
Product ID
S-CKO-02442
Gene Alias
Fkh16; Foxm1b; HFH-11B; MPHOSPH2; Mpm2; WIN
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Foxm1em1flox/Cya mice (Catalog S-CKO-02442) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000073316
NCBI RefSeq
NM_008021
Target Region
Exon 3~5
Size of Effective Region
~4.5 kb
Detailed Document
Overview of Gene Research
Foxm1, or Forkhead box M1, is a key transcriptional regulator involved in numerous biological processes in mammals, such as carbohydrate and lipid metabolism, aging, immune regulation, development, and disease [2]. It acts through mediating transcription activation and inhibition and interacting with various transcriptional co-regulators, like MuvB complexes, STAT3, and β-catenin [4].
In cancer, Foxm1 is a critical molecule. It regulates multiple aspects of cancer cells, including growth, metastasis, recurrence, and stem cell features [1]. For example, in gastric cancer, RNF112-mediated ubiquitination of Foxm1 suppresses the proliferation and invasion of cancer cells [3]. Foxm1 also impacts the outcomes of targeted therapies, chemotherapies, and immune checkpoint inhibitors in various cancer types [1].
In non-malignant diseases, Foxm1 expression is involved in the development or repair of multiple conditions, including pulmonary fibrosis, diabetes, and liver injury repair, through complex mechanisms involving multiple signaling pathways like WNT/β-catenin and STAT3/FOXM1/GLUT1 [4].
In conclusion, Foxm1 is a multifaceted transcriptional regulator with significant roles in both normal biological processes and disease conditions. Its study, especially through gene knockout (KO) or conditional knockout (CKO) mouse models as suggested in some of the research directions, could potentially lead to a better understanding of its functions and provide new therapeutic strategies for cancer and non-malignant diseases.
References:
1. Khan, Md Arafat, Khan, Parvez, Ahmad, Aatiya, Fatima, Mahek, Nasser, Mohd Wasim. 2023. FOXM1: A small fox that makes more tracks for cancer progression and metastasis. In Seminars in cancer biology, 92, 1-15. doi:10.1016/j.semcancer.2023.03.007. https://pubmed.ncbi.nlm.nih.gov/36958703/
2. Li, Mengxi, Gao, Xuzheng, Su, Yanting, Zhang, Zhenwang, Zhu, Dan. 2024. FOXM1 transcriptional regulation. In Biology of the cell, 116, e2400012. doi:10.1111/boc.202400012. https://pubmed.ncbi.nlm.nih.gov/38963053/
3. Zhang, Shengwei, Wang, Jing, Hu, Weichao, Yang, Shiming, Hu, Changjiang. 2023. RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer. In JCI insight, 8, . doi:10.1172/jci.insight.166698. https://pubmed.ncbi.nlm.nih.gov/37288663/
4. Zhang, Zhenwang, Li, Mengxi, Sun, Tian, Zhang, Zhengrong, Liu, Chao. 2023. FOXM1: Functional Roles of FOXM1 in Non-Malignant Diseases. In Biomolecules, 13, . doi:10.3390/biom13050857. https://pubmed.ncbi.nlm.nih.gov/37238726/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen