C57BL/6JCya-Gstm1em1flox/Cya
Common Name:
Gstm1-flox
Product ID:
S-CKO-02776
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Gstm1-flox
Strain ID
CKOCMP-14862-Gstm1-B6J-VA
Gene Name
Product ID
S-CKO-02776
Gene Alias
Gstb-1; Gstb1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gstm1em1flox/Cya mice (Catalog S-CKO-02776) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000004140
NCBI RefSeq
NM_010358
Target Region
Exon 3~5
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Gstm1, glutathione S-transferase M1, is an enzyme-encoding gene. The Gstm1-encoded enzyme is responsible for the detoxification of substances harmful to the human body, such as air pollution, drugs, pesticides, and tobacco [1].
In terms of disease associations, some meta-analyses suggest that the GSTM1 null genotype may not be associated with pre-eclampsia risk [2], renal cell carcinoma risk [3], basal and squamous cell carcinomas risk [4], or hypertension risk [5]. However, in Chinese populations, the GSTM1 null genotype was associated with an increased risk of lung cancer [6]. In Asians, the GSTM1 null genotype may be associated with a higher risk of oral cancer, and this effect may be modified by smoking status [7]. Also, in a meta-analysis, the GSTM1 null genotype was associated with the development of cervical cancer, especially in Chinese and Indian populations, and smoking modified this association [8].
In conclusion, Gstm1 plays a crucial role in the detoxification process. Research on its null genotype through meta-analyses of case-control studies has revealed its potential associations with various diseases, including lung, oral, and cervical cancers, indicating its significance in understanding disease susceptibility and the influence of genetic factors in different ethnic groups.
References:
1. Nakanishi, Giovana, Bertagnolli, Laísa S, Pita-Oliveira, Murilo, Cirino, Heithor S, Rodrigues-Soares, Fernanda. 2022. GSTM1 and GSTT1 polymorphisms in healthy volunteers - a worldwide systematic review. In Drug metabolism reviews, 54, 37-45. doi:10.1080/03602532.2022.2036996. https://pubmed.ncbi.nlm.nih.gov/35103568/
2. Li, Lin, Wang, Ao, Ke, Yi. . GSTM1 and GSTT1 polymorphisms and risk of preeclampsia: a system review and meta-analysis. In The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 36, 2237623. doi:10.1080/14767058.2023.2237623. https://pubmed.ncbi.nlm.nih.gov/37469043/
3. Liu, Rui, Wang, Xiao-Hua, Liu, Li, Zhou, Qiang. . No association between the GSTM1 null genotype and risk of renal cell carcinoma: a meta-analysis. In Asian Pacific journal of cancer prevention : APJCP, 13, 3109-12. doi:. https://pubmed.ncbi.nlm.nih.gov/22994718/
4. Peng, Hao, He, Quanyong, Zhu, Jie, Peng, Cheng. 2012. Effect of GSTM1 polymorphism on risks of basal cell carcinoma and squamous cell carcinoma: a meta-analysis. In Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34, 675-81. doi:10.1007/s13277-012-0595-9. https://pubmed.ncbi.nlm.nih.gov/23184764/
5. Ge, Beihai, Song, Yadong, Zhang, Yi, Wen, Yuxiang, Guo, Xiaomei. 2015. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null polymorphisms and the risk of hypertension: a meta-analysis. In PloS one, 10, e0118897. doi:10.1371/journal.pone.0118897. https://pubmed.ncbi.nlm.nih.gov/25742618/
6. Shi, Xiuquan, Zhou, Suhua, Wang, Zhongxu, Zhou, Zongcan, Wang, Zengzhen. 2007. CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. In Lung cancer (Amsterdam, Netherlands), 59, 155-63. doi:. https://pubmed.ncbi.nlm.nih.gov/17900751/
7. Zhang, Zhi-Jiang, Hao, Ke, Shi, Rong, Xu, Xiaohui, Ma, Jin. 2011. Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis. In American journal of epidemiology, 173, 847-57. doi:10.1093/aje/kwq480. https://pubmed.ncbi.nlm.nih.gov/21436184/
8. Liu, Ying, Xu, Liang-Zhi. . Meta-analysis of association between GSTM1 gene polymorphism and cervical cancer. In Asian Pacific journal of tropical medicine, 5, 480-4. doi:10.1016/S1995-7645(12)60083-2. https://pubmed.ncbi.nlm.nih.gov/22575983/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen