C57BL/6JCya-Cnmdem1flox/Cya
Common Name:
Cnmd-flox
Product ID:
S-CKO-03374
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Cnmd-flox
Strain ID
CKOCMP-16840-Cnmd-B6J-VA
Gene Name
Product ID
S-CKO-03374
Gene Alias
Bricd3; ChM-I; Chmd; Lect1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
14
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cnmdem1flox/Cya mice (Catalog S-CKO-03374) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000165835
NCBI RefSeq
NM_001310655
Target Region
Exon 5
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Chondromodulin-I (Cnmd), also known as Chm-1, Chm-I, or Lect1, is a gene encoding a 334-amino-acid type II transmembrane glycoprotein. It is primarily expressed in cartilage and plays crucial roles in chondrocyte proliferation, cartilage homeostasis, and angiogenesis blocking. It is also involved in bone repair and may delay osteoarthritis (OA) progression. Its down-regulation is correlated with OA severity, suggesting its potential as a therapeutic target [1,3].
In a mouse model of distraction osteogenesis, Cnmd null (Cnmd-/-) mice showed less cartilage callus formation, with the distraction gap filled by fibrous tissues. Radiological and histological investigations demonstrated delayed bone consolidation and remodeling of the lengthened segment. Cnmd deficiency also caused a one-week delay in the peak expression of VEGF, MMP2, and MMP9 genes and subsequent angiogenesis and osteoclastogenesis, indicating that Cnmd is necessary for cartilage callus distraction [2].
In conclusion, Cnmd is essential for cartilage-related biological processes such as chondrocyte growth, cartilage callus distraction, and bone repair. Mouse models with Cnmd deficiency have revealed its importance in these processes, and its potential role in OA. Understanding Cnmd may provide new therapeutic strategies for OA and other cartilage-related diseases [1,2,3].
References：
1. Reyes Alcaraz, Viviana, Pattappa, Girish, Miura, Shigenori, Shukunami, Chisa, Docheva, Denitsa. 2024. A Narrative Review of the Roles of Chondromodulin-I (Cnmd) in Adult Cartilage Tissue. In International journal of molecular sciences, 25, . doi:10.3390/ijms25115839. https://pubmed.ncbi.nlm.nih.gov/38892027/
2. Yukata, Kiminori, Shukunami, Chisa, Matsui, Yoshito, Hiraki, Yuji, Yasui, Natsuo. 2023. Chondromodulin is necessary for cartilage callus distraction in mice. In PloS one, 18, e0280634. doi:10.1371/journal.pone.0280634. https://pubmed.ncbi.nlm.nih.gov/36795722/
3. Zhu, Sipin, Qiu, Heng, Bennett, Samuel, Xu, Huazi, Xu, Jiake. 2019. Chondromodulin-1 in health, osteoarthritis, cancer, and heart disease. In Cellular and molecular life sciences : CMLS, 76, 4493-4502. doi:10.1007/s00018-019-03225-y. https://pubmed.ncbi.nlm.nih.gov/31317206/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen