Tes, also known as testin LIM domain protein, contains three LIM domains which are specific interacting regions for cell adhesion and cytoskeleton regulatory proteins. It functions as a Mena-dependent tumor suppressor. Mena is a cytoskeleton regulator that interacts with Lamellipodin (Lpd) to regulate actin filament assembly, cell adhesion and motility. Thus, Tes may play a role in regulating these cellular processes and has potential importance in cancer-related biological processes [1].

In gastric cancer, Tes was found to suppress cell proliferation and colony formation, induce cell cycle arrest, inhibit tumorigenicity in vitro, as well as inhibit cell migration and invasion in vitro and metastasis in vivo. It does this by interacting with Mena and inhibiting the interaction between Mena and Lpd. In gastric cancer patients with high Mena expression, the expression of Tes was associated with tumor infiltration, lymph node metastasis, TNM stage, and prognosis [1].

In conclusion, Tes functions as a Mena-dependent tumor suppressor, especially in gastric cancer. The study of Tes in gastric cancer, through in-vivo and functional studies, helps to understand the mechanisms of cancer carcinogenesis and metastasis, providing potential targets for gastric cancer treatment.