C57BL/6JCya-Pilraem1flox/Cya
Common Name:
Pilra-flox
Product ID:
S-CKO-07490
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Pilra-flox
Strain ID
CKOCMP-231805-Pilra-B6J-VA
Gene Name
Product ID
S-CKO-07490
Gene Alias
FDF03
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pilraem1flox/Cya mice (Catalog S-CKO-07490) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000058897
NCBI RefSeq
NM_153510
Target Region
Exon 1~2
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Pilra, or paired immunoglobulin-like type 2 receptor alpha, is a cell-surface inhibitory receptor. It plays a role in regulating immune responses, and is involved in pathways related to inflammation and immunity [2,5]. It has significance in maintaining CD8+ T cell quiescence through interaction with CD8α [4]. Additionally, it is an entry co-receptor for herpes simplex virus-1 [1].
Genetically, Pilra has been associated with several diseases. In Alzheimer's disease (AD), the Pilra-A allele (rs1859788 A > G) shows negative interactions with APOE risk variants and GM17, suggesting it modifies the effect of these high-risk variants on future AD risk [1]. Also, the R78 (rs1859788) variant correlates with higher HSV-1-specific IgG titers in AD patients [3]. In atrial fibrillation, Pilra is closely related to multiple types of immune cell infiltration, which may be associated with the disease and could be a novel intervention target [2]. In pan-cancer analysis, Pilra was significantly dysregulated and mutated, impacting patient prognosis, immune cell infiltration, and cancer immunotherapy outcomes [5].
In conclusion, Pilra is a key regulator in immune-related functions. Its study, especially through genetic associations in models, has provided insights into its role in diseases such as Alzheimer's disease, atrial fibrillation, and cancer. Understanding Pilra's functions can potentially offer new directions for therapeutic interventions in these disease areas.
References：
1. Lopatko Lindman, Karin, Jonsson, Caroline, Weidung, Bodil, Elgh, Fredrik, Lövheim, Hugo. 2022. PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk. In Scientific reports, 12, 13264. doi:10.1038/s41598-022-17058-6. https://pubmed.ncbi.nlm.nih.gov/35918447/
2. Shi, Weihua, Li, Xiaoli, Su, Yongxing, Zhong, Guoqiang, Jiang, Zhiyuan. 2023. PILRA is associated with immune cells infiltration in atrial fibrillation based on bioinformatics and experiment validation. In Frontiers in cardiovascular medicine, 10, 1082015. doi:10.3389/fcvm.2023.1082015. https://pubmed.ncbi.nlm.nih.gov/37396579/
3. Agostini, Simone, Costa, Andrea Saul, Mancuso, Roberta, Nemni, Raffaello, Clerici, Mario. 2019. The PILRA G78R Variant Correlates with Higher HSV-1-Specific IgG Titers in Alzheimer's Disease. In Cellular and molecular neurobiology, 39, 1217-1221. doi:10.1007/s10571-019-00712-5. https://pubmed.ncbi.nlm.nih.gov/31297637/
4. Zheng, Linghua, Han, Xue, Yao, Sheng, Quinlan, Edward, Chen, Lieping. 2022. The CD8α-PILRα interaction maintains CD8+ T cell quiescence. In Science (New York, N.Y.), 376, 996-1001. doi:10.1126/science.aaz8658. https://pubmed.ncbi.nlm.nih.gov/35617401/
5. Li, Qiao, Yang, Zhirong, He, Xiaoyan, Yang, Xin. 2023. Comprehensive analysis of PILRΑ's association with the prognosis, tumor immune infiltration, and immunotherapy in pan-cancer. In Scientific reports, 13, 14334. doi:10.1038/s41598-023-41649-6. https://pubmed.ncbi.nlm.nih.gov/37652967/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen