C57BL/6JCya-Smtnem1flox/Cya
Common Name:
Smtn-flox
Product ID:
S-CKO-10177
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Smtn-flox
Strain ID
CKOCMP-29856-Smtn-B6J-VA
Gene Name
Product ID
S-CKO-10177
Gene Alias
smsmo
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Smtnem1flox/Cya mice (Catalog S-CKO-10177) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000170588
NCBI RefSeq
NM_001159284
Target Region
Exon 13~17
Size of Effective Region
~3.0 kb
Detailed Document
Overview of Gene Research
Smtn, encoding smoothelin-A and smoothelin-B, is a gene related to cytoskeletal proteins in smooth muscle cells. Smoothelins are part of a protein family characterized by a single C-terminal type-2 calponin homology (CH) domain. They act as structural components of the contractile apparatus in smooth muscle cells, influencing the contractile potential of these cells [1].
Studies on Smtn-deficient mouse models have provided valuable insights. In mice lacking smoothelin-B (Smtn-B(-/-)), the contractile capacity of the saphenous and femoral arteries was strongly reduced, regardless of the contractile agonist. Paradoxically, this was accompanied by increased mean arterial pressure and concomitant cardiac hypertrophy [2].
In conclusion, Smtn plays a key role in determining arterial smooth muscle contractility. The study of Smtn-deficient mouse models, especially those lacking smoothelin-B, has revealed its significance in cardiovascular performance, suggesting that further research on the Smtn gene in relation to hypertension and other cardiovascular diseases in humans is warranted [2].
References：
1. Murali, Megha, MacDonald, Justin A. 2017. Smoothelins and the Control of Muscle Contractility. In Advances in pharmacology (San Diego, Calif.), 81, 39-78. doi:10.1016/bs.apha.2017.10.001. https://pubmed.ncbi.nlm.nih.gov/29310803/
2. Rensen, Sander S, Niessen, Petra M, van Deursen, Jan M, De Mey, Jo G R, van Eys, Guillaume J. 2008. Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice. In Circulation, 118, 828-36. doi:10.1161/CIRCULATIONAHA.107.743690. https://pubmed.ncbi.nlm.nih.gov/18678771/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen