C57BL/6JCya-Krt78em1flox/Cya
Common Name:
Krt78-flox
Product ID:
S-CKO-10736
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Krt78-flox
Strain ID
CKOCMP-332131-Krt78-B6J-VA
Gene Name
Product ID
S-CKO-10736
Gene Alias
2310030B04Rik; Kb40
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Krt78em1flox/Cya mice (Catalog S-CKO-10736) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000164932
NCBI RefSeq
NM_212487
Target Region
Exon 3~4
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Krt78, a member of the keratin gene family, may play a role in processes like keratinization [2,5]. Keratins are intermediate filament proteins important for maintaining the structural integrity of epithelial cells. Although not many studies detail its specific associated pathways, it's likely involved in pathways related to cell structure and differentiation. Genetic models could potentially be valuable in further exploring its functions.
Krt78 has been associated with several diseases. In head and neck squamous cell carcinoma (HNSCC), its expression levels correlate with infiltration levels of CD8+ T cells and macrophages, and also with overall survival. Protein expression levels of Krt78 in HNSCC are significantly lower than in normal tissues, suggesting it might serve as a diagnostic and prognostic biomarker [1]. In oropharyngeal carcinoma, Krt78 shows low expression, and in laryngeal squamous cell carcinoma, it was identified as one of the hub genes through weighted gene co-expression network analysis [4,7]. In metastatic melanoma, Krt78 was among the hub genes involved in immune response and tumor cell development [6]. In silicosis, the plasma level of TNF-α was negatively correlated with the expression of exosomal Krt78 [3].
In conclusion, Krt78 appears to be involved in multiple disease-related processes, especially in cancers like HNSCC, oropharyngeal carcinoma, laryngeal squamous cell carcinoma, and metastatic melanoma. Its potential as a biomarker in these diseases, along with its relationship to immune cell infiltration and cytokine levels in silicosis, highlights its importance in disease diagnosis and prognosis. The study of Krt78 in these disease areas provides insights into disease mechanisms and potential diagnostic or prognostic strategies [1,3,4,6,7].
References:
1. Guo, Qiaojuan, Lu, Tianzhu, Xu, Hanchuan, Lin, Mengyao, Guo, Fang. 2023. Identification of immune-related genes contributing to head and neck squamous cell carcinoma development using weighted gene co-expression network analysis. In Cancer reports (Hoboken, N.J.), 6, e1808. doi:10.1002/cnr2.1808. https://pubmed.ncbi.nlm.nih.gov/37092360/
2. Cheon, Jaehwan, Kim, Byoungjae, Park, Jaehyung, Shin, Jaemin, Kim, Tae Hoon. 2024. Unveiling Biomarkers in Head and Neck Squamous Cell Carcinoma through Bioinformatics: The Role of SPP1 and KRT78. In International journal of molecular sciences, 25, . doi:10.3390/ijms252212062. https://pubmed.ncbi.nlm.nih.gov/39596132/
3. Yao, Jiahui, Li, Yongxin, Wang, Shujuan, Li, Guohui, Lou, Jianlin. 2024. Exosomal proteomics and cytokine analysis distinguish silicosis cases from controls. In Environmental pollution (Barking, Essex : 1987), 357, 124469. doi:10.1016/j.envpol.2024.124469. https://pubmed.ncbi.nlm.nih.gov/38945194/
4. Dawood, Ali Adel. 2023. Uneven Expression of 20 Human Papillomavirus Genes Associated with Oropharyngeal Carcinoma. In Rambam Maimonides medical journal, 14, . doi:10.5041/RMMJ.10508. https://pubmed.ncbi.nlm.nih.gov/37917867/
5. Wu, Jiayuan, Wu, Tianyi, Xie, Xueyuan, Li, Junya, Xu, Lingyang. 2023. Genetic Association Analysis of Copy Number Variations for Meat Quality in Beef Cattle. In Foods (Basel, Switzerland), 12, . doi:10.3390/foods12213986. https://pubmed.ncbi.nlm.nih.gov/37959106/
6. Wang, Li-Xin, Li, Yang, Chen, Guan-Zhi. 2018. Network-based co-expression analysis for exploring the potential diagnostic biomarkers of metastatic melanoma. In PloS one, 13, e0190447. doi:10.1371/journal.pone.0190447. https://pubmed.ncbi.nlm.nih.gov/29377892/
7. Liu, Jian, Zhao, Jing, Xu, Jiaran, Bai, Guangping, Guo, Zhiqiang. 2022. SPINK5 is a Prognostic Biomarker Associated With the Progression and Prognosis of Laryngeal Squamous Cell Carcinoma Identified by Weighted Gene Co-Expression Network Analysis. In Evolutionary bioinformatics online, 18, 11769343221077118. doi:10.1177/11769343221077118. https://pubmed.ncbi.nlm.nih.gov/35140453/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen