C57BL/6NCya-Snw1em1flox/Cya
Common Name:
Snw1-flox
Product ID:
S-CKO-13029
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Snw1-flox
Strain ID
CKOCMP-66354-Snw1-B6N-VA
Gene Name
Product ID
S-CKO-13029
Gene Alias
2310008B08Rik; NCoA-62; SKIP; Skiip
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
12
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Snw1em1flox/Cya mice (Catalog S-CKO-13029) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000021428
NCBI RefSeq
NM_025507
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
Snw1, also known as Ski-interacting protein, is a nuclear receptor co-activator involved in multiple crucial biological processes. It participates in splicing and transcription control, including being associated with pathways like androgen receptor signaling, NF-κB pathway, and Notch signaling. It is also involved in cell-cycle progression, inflammatory responses, and antiviral innate immune responses [1,2,3,4].
In prostate cancer, overexpression of Snw1 is an independent prognostic marker, with stronger expression in TMPRSS2:ERG fusion-positive cancers. This indicates its potential clinical utility in prostate cancer prognosis [1].
In the NF-κB pathway, Snw1 detaches from its splicing complex upon NF-κB activation, binds to p-TEFb, and is indispensable for the transcriptional elongation of NF-κB target genes [2].
In neuroblastoma, Snw1 interacts with RBPJ to regulate the Notch signaling pathway, and both are upregulated, being associated with unfavorable patient outcomes [3].
Regarding antiviral innate immune responses, Snw1 positively regulates the expression of pro-inflammatory cytokines and IFN responses against influenza A virus infection, promoting NF-κB activation and TBK1 phosphorylation by interacting with IKKγ [4].
In cardiac hypertrophy, Antrodia cinnamomea triterpenoids can upregulate ALDH2 expression via regulating the Snw1/RXR axis [5].
In vertebrate embryos, Snw1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification [6].
In summary, Snw1 plays essential roles in various biological processes and diseases. Its functions in cancer prognosis, inflammation-related pathways, antiviral immunity, cardiac hypertrophy, and embryonic development have been revealed through multiple studies. These findings contribute to a better understanding of the biological functions of Snw1 and provide potential therapeutic targets for related diseases.
References:
1. Höflmayer, Doris, Willich, Carla, Hube-Magg, Claudia, Wilczak, Waldemar, Bernreuther, Christian. 2019. SNW1 is a prognostic biomarker in prostate cancer. In Diagnostic pathology, 14, 33. doi:10.1186/s13000-019-0810-8. https://pubmed.ncbi.nlm.nih.gov/31043167/
2. Verma, Suneer, De Jesus, Paul, Chanda, Sumit K, Verma, Inder M. 2019. SNW1, a Novel Transcriptional Regulator of the NF-κB Pathway. In Molecular and cellular biology, 39, . doi:10.1128/MCB.00415-18. https://pubmed.ncbi.nlm.nih.gov/30397075/
3. Hong, Mei, He, Jing, Li, Shiwang. 2019. SNW1 regulates Notch signaling in neuroblastoma through interacting with RBPJ. In Biochemical and biophysical research communications, 509, 869-876. doi:10.1016/j.bbrc.2019.01.036. https://pubmed.ncbi.nlm.nih.gov/30642633/
4. Zhang, Qiao, Liang, Taizhen, Gu, Shuyin, Ye, Yilu, Liu, Shuwen. 2020. SNW1 interacts with IKKγ to positively regulate antiviral innate immune responses against influenza A virus infection. In Microbes and infection, 22, 576-584. doi:10.1016/j.micinf.2020.07.009. https://pubmed.ncbi.nlm.nih.gov/32805409/
5. Ma, Yinghua, Wang, Yunxia, Anwaier, Gulinigaer, Zeng, Kewu, Qi, Rong. 2024. Antrodia cinnamomea triterpenoids attenuate cardiac hypertrophy via the SNW1/RXR/ALDH2 axis. In Redox biology, 78, 103437. doi:10.1016/j.redox.2024.103437. https://pubmed.ncbi.nlm.nih.gov/39591904/
6. Wu, Mary Y, Ramel, Marie-Christine, Howell, Michael, Hill, Caroline S. 2011. SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos. In PLoS biology, 9, e1000593. doi:10.1371/journal.pbio.1000593. https://pubmed.ncbi.nlm.nih.gov/21358802/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen